Epilepsy, Part II: Treatment (Handbook of Clinical Neurology)
This information paves a way for future translational studies. Chapter 48, authored by Robert D. Fealey, deals with thermoregulation in neuropathies. It is a useful, comprehensive source of new data related to thermoregulatory sweating impairment in neuropathy. The major message of the chapter is that targeted temperature management trials, unfortunately, were not effective in decreasing brain damage in traumatic brain injury or stroke, whether ischemic or hemorrhagic. Despite the negative results of these trials, the targeted temperature management approach continues to be investigated in clinical trials see also chapter Chapter 50, authored by Mike J.
Price1 and Michelle Trbovich, deals with thermoregulation following spinal cord injury. It is evident that there is a reduced afferent input to the brain and a decrease in the efferent output to thermoeffectors cutaneous vasomotor and sweating below the level of spinal cord lesion. The chapter ends with a message that physical fitness is an important component in decreasing dysfunctions of thermoregulation in patients with spinal cord injury.
Lyden, describe the use of hypothermia in acute ischemic stroke therapy. They emphasize that therapeutic hypothermia has proved to be an extremely powerful neuroprotectant and is the most promising treatment for patients with acute ischemic stroke. In particular, it preserves neuronal vitality by modulating several metabolic pathways, inflammation, apoptosis, and preservation of the neurovascular unit.
Furthermore, new modes of hypothermic treatment that combine cooling with other therapeutic modalities such as thrombolysis and new technologies allowing safer and faster improvement of the patient are discussed. The next chapter 52 follows up on this subject by discussing other aspects of neuroprotection. Still, the authors of this chapter, Jae H. Choi and John Pile-Spellman, provide a sophisticated practical description of the novel techniques available in the field. Also, attention is called by the authors to novel invasive extracorporeal techniques and minimally invasive endovascular intra-arterial systems that are under development for more effective selective cooling of specific brain areas.
An emerging therapeutic method used in oncology is discussed in chapter 53 by Riadh W. In particular, the application of therapeutic hyperthermia alone or in combination with other therapeutic modalities is described. Emphasis is given to the technical limitations and standardization of heat delivery to the tumor site.
The viability of heat therapy in oncology has been increased drastically due to the development of modern hardware and software for heat delivery and temperature measurement. The concluding chapter 54 is a state-of-the-art summary of antipyretic therapy, an important filed of clinical pharmacology. Simmons, start with the classical antipyretic drug, aspirin, the fever-reducing effect of which has turned out to be due to inhibiting prostaglandin synthesis. A systematic treatise of the biochemistry of enzymes and receptors involved in prostaglandin-mediated signal transduction, including — among others — prostaglandin H2, prostaglandin E2, and EP receptors, constitutes the largest part of this chapter.
The TRPV1 channel is also discussed. The chapter ends with a discussion of the clinical use of established antipyretics, as well as of novel medicinal agents under clinical trials and topics for future research.sisanamehos.cf
Anticonvulsant therapy in brain-tumor related epilepsy : Journal of Epileptology
The two-volume handbook [ 1 Romanovsky AA , editor. This timely publication, edited and written by experts in all important aspects of thermoregulation, can be recommended to scientists, neurologists and anyone who may be interested in the thermoregulation aspects of biology and medicine, broadly defined. Skip to Main Content. Search in: This Journal Anywhere. Advanced search. Journal Temperature Volume 6, - Issue 1. Submit an article Journal homepage. Pages Accepted author version posted online: 27 Oct Front Matter: Book Review.
Thermoregulation: From basic neuroscience to clinical neurology, part 2. Section VI: Normal and abnormal body core and peripheral temperatures This section starts with the description of the modern methods of measuring body temperature in animal experiments and in human clinical practice chapter 29, Body temperature and clinical thermometry , expertly written by Charmaine Childs.
Section VII: Thermoregulation in neurological disease This section is dedicated to the thermoregulatory dysfunctions occurring in neurological diseases. Conclusion The two-volume handbook [ 1 Romanovsky AA , editor. Article Metrics Views. Article metrics information Disclaimer for citing articles. More Share Options. Economic and psychosocial issues such as stigma are fully covered. The special problems of epilepsy treatment in the developing world are described. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content.
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